A new class of unusually potent antitumor drugs modeled after the alkylating antibiotic CC-1065 (isolated from Streptomyces zelensis) are being developed as clinical candidates. Based upon observations of the parent drug a number of novel features have been noted. The drugs bind within the minor groove of DNA in a highly sequence specific manner. A covalent bond is formed with N3 of adenine under proper steric conditions. While the unusually high cytoxicity activity (at

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA028495-11
Application #
3168181
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1980-07-01
Project End
1994-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
11
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
City
Buffalo
State
NY
Country
United States
Zip Code
14263
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