Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA029360-13
Application #
2087919
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1980-12-01
Project End
1995-04-30
Budget Start
1994-12-01
Budget End
1995-04-30
Support Year
13
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Wayne State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Ramachandran, C; Kunikane, H; You, W et al. (1998) Phorbol ester-induced P-glycoprotein phosphorylation and functionality in the HTB-123 human breast cancer cell line. Biochem Pharmacol 56:709-18
Ramachandran, C; You, W; Krishan, A (1997) Bcl-2 and mdr-1 gene expression during doxorubicin-induced apoptosis in murine leukemic P388 and P388/R84 cells. Anticancer Res 17:3369-76
Mou, C; Ganju, N; Sridhar, K S et al. (1997) Simultaneous quantitation of plasma doxorubicin and prochlorperazine content by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 703:217-24
Krishan, A; Fitz, C M; Andritsch, I (1997) Drug retention, efflux, and resistance in tumor cells. Cytometry 29:279-85
Kunikane, H; Zalupski, M M; Ramachandran, C et al. (1997) Flow cytometric analysis of P-glycoprotein expression and drug efflux in human soft tissue and bone sarcomas. Cytometry 30:197-203
Ramachandran, C; Mead, D; Wellham, L L et al. (1995) Expression of drug resistance-associated mdr-1, GST pi, and topoisomerase II genes during cell cycle traverse. Biochem Pharmacol 49:545-52
Isobe, H; Sridhar, K S; Doria, R et al. (1995) Prognostic significance of DNA aneuploidy in diffuse malignant mesothelioma. Cytometry 19:86-91
Isobe, H; Wellham, L; Sauerteig, A et al. (1994) Doxorubicin retention and chemoresistance in human mesothelioma cell lines. Int J Cancer 57:581-5
Sridhar, K S; Krishan, A; Samy, T S et al. (1994) Phase I and pharmacokinetics studies of prochlorperazine 2-h i.v. infusion as a doxorubicin-efflux blocker. Cancer Chemother Pharmacol 34:377-84
Ramachandran, C; Samy, T S; Huang, X L et al. (1993) Doxorubicin-induced DNA breaks, topoisomerase II activity and gene expression in human melanoma cells. Biochem Pharmacol 45:1367-71

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