The proposed is a population-based case-control study designed to elucidate further the etiology of cancers of the larynx, esophagus and oral cavity. Specifically, this study is designed: 1) to identify the mechanisms by which alcohol enhances the risk of these cancers; 2) to determine whether host susceptibility to alcohol is related to risk; 3) to determine whether dietary deficiencies of such nutrients as vitamins A and C, zinc, iron and others enhance the risk of these neoplasms; 4) to clarify the role of dental health and care in the genesis of these cancers; 5) to identify occupational exposures that increase the risk of these neoplasms; and 6) to compare epidemiologic features of these neoplasms according to specific subsites therein. Cases, identified through the population-based SEER tumor registry in Northwestern Washington State, will consist of all persons diagnosed with one of the three cancers under study in King, Pierce and Snohomish counties between 9/1/82 and 2/28/86. Controls will be randomly selected from the same three county populations to equal the number of cases of oral cancer identified and to be of the same age and sex composition as the overall case group. Thus, a single control group, protocol and set of study instruments will be used to study all three groups of cancer cases. Each subject will be interviewed in their home to ascertain detailed information on prior use of tobacco and alcohol, dietary intake, dental health, and several other relevant factors of etiologic interest. In addition, dental information will be abstracted from each subject's dental records in a standardized format. It is anticipated that the results of this investigation will not only further the understanding of factors that lead to the development of the cancers under study and provide additional etiologic leads to be pursued, but will also provide comprehensive information regarding alcohol use and abuse and diet and nutrition in a general population sample of individuals.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA030022-03
Application #
3168993
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1983-08-01
Project End
1988-01-31
Budget Start
1986-02-01
Budget End
1987-01-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Toporcov, Tatiana Natasha; Znaor, Ariana; Zhang, Zuo-Feng et al. (2015) Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium. Int J Epidemiol 44:169-85
Conway, David I; Brenner, Darren R; McMahon, Alex D et al. (2015) Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries. Int J Cancer 136:1125-39
Galeone, Carlotta; Turati, Federica; Zhang, Zuo-Feng et al. (2015) Relation of allium vegetables intake with head and neck cancers: evidence from the INHANCE consortium. Mol Nutr Food Res 59:1641-50
Marks, Morgan A; Chaturvedi, Anil K; Kelsey, Karl et al. (2014) Association of marijuana smoking with oropharyngeal and oral tongue cancers: pooled analysis from the INHANCE consortium. Cancer Epidemiol Biomarkers Prev 23:160-71
Leoncini, Emanuele; Ricciardi, Walter; Cadoni, Gabriella et al. (2014) Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium. Eur J Epidemiol 29:35-48
Stott-Miller, Marni; Chen, Chu; Chuang, Shu-Chun et al. (2012) History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortium. Cancer Epidemiol Biomarkers Prev 21:294-304
Chuang, Shu-Chun; Jenab, Mazda; Heck, Julia E et al. (2012) Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium. Cancer Causes Control 23:69-88
Freedman, Neal D; Murray, Liam J; Kamangar, Farin et al. (2011) Alcohol intake and risk of oesophageal adenocarcinoma: a pooled analysis from the BEACON Consortium. Gut 60:1029-37
Deleyiannis, F W; Thomas, D B (1997) Risk of lung cancer among patients with head and neck cancer. Otolaryngol Head Neck Surg 116:630-6
Vaughan, T L; Stewart, P A; Davis, S et al. (1997) Work in dry cleaning and the incidence of cancer of the oral cavity, larynx, and oesophagus. Occup Environ Med 54:692-5

Showing the most recent 10 out of 18 publications