Abstract

The goal of this research is to seek identifiable genetic markers whose inheritance is linked with that of multiple endocrine neoplasia, type II (MEN II), and to screen individuals to detect preclinical onset of the disease. Approximately 240 individuals will be screened for a wide variety of genetic markers in the attempt to identify genetic marker loci that are closely linked to the locus at which the cancer gene is segregating. This information will be used to identify individuals at high risk for inheriting the gene. Endocrinological screening is continued in the attempt to detect early manifestations of the disease in sufficient time so that advanced carcinoma can be avoided. (5)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA032066-05
Application #
3170107
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1983-06-01
Project End
1992-05-31
Budget Start
1988-06-01
Budget End
1989-05-31
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Gill, J R; Reyes-Mugica, M; Iyengar, S et al. (1996) Early presentation of metastatic medullary carcinoma in multiple endocrine neoplasia, type IIA: implications for therapy. J Pediatr 129:459-64
Lichter, J B; Difilippantonio, M J; Pakstis, A J et al. (1993) Physical and genetic maps for chromosome 10. Genomics 16:320-4
Lichter, J B; Wu, J; Brooks-Wilson, A R et al. (1993) A new polymorphic marker (D10S97) tightly linked to the multiple endocrine neoplasia type 2A (MEN2A) locus. Hum Genet 90:516-20
Brooks-Wilson, A R; Lichter, J B; Ward, D C et al. (1993) Genomic and yeast artificial chromosome long-range physical maps linking six loci in 10q11.2 and spanning the multiple endocrine neoplasia type 2A (MEN2A) region. Genomics 17:611-7
Lichter, J B; Difilippantonio, M; Wu, J et al. (1992) Localization of the gene for MEN 2A. Henry Ford Hosp Med J 40:199-204
Lichter, J B; Wu, J S; Genel, M et al. (1992) Presymptomatic testing using DNA markers for individuals at risk for familial multiple endocrine neoplasia 2A. J Clin Endocrinol Metab 74:368-73
Lichter, J B; Wu, J; Miller, D et al. (1992) A high-resolution meiotic mapping panel for the pericentromeric region of chromosome 10. Genomics 13:607-12
Carson, N L; Wu, J S; Jackson, C E et al. (1990) The mutation for medullary thyroid carcinoma with parathyroid tumors (MTC with PTs) is closely linked to the centromeric region of chromosome 10. Am J Hum Genet 47:946-51
Kidd, J R; Matsubara, Y; Castiglione, C M et al. (1990) The locus for the medium-chain acyl-CoA dehydrogenase gene on chromosome 1 is highly polymorphic. Genomics 6:89-93
Kidd, K K; Simpson, N E (1990) Search for the gene for multiple endocrine neoplasia type 2A. Recent Prog Horm Res 46:305-41;discussion 341-3

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