Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA033017-03S1
Application #
3170924
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1982-07-01
Project End
1985-08-31
Budget Start
1984-07-01
Budget End
1985-08-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Sarup, J C; Johnson, M A; Verhoef, V et al. (1989) Regulation of purine deoxynucleoside phosphorylation by deoxycytidine kinase from human leukemic blast cells. Biochem Pharmacol 38:2601-7
Johnson, M A; Ahluwalia, G; Connelly, M C et al. (1988) Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells. J Biol Chem 263:15354-7
Fridland, A; Verhoef, V (1987) Mechanism for ara-CTP catabolism in human leukemic cells and effect of deaminase inhibitors on this process. Semin Oncol 14:262-8
Sarup, J C; Fridland, A (1987) Identification of purine deoxyribonucleoside kinases from human leukemia cells: substrate activation by purine and pyrimidine deoxyribonucleosides. Biochemistry 26:590-7
Johnson, M A; Johns, D G; Fridland, A (1987) 2',3'-Dideoxynucleoside phosphorylation by deoxycytidine kinase from normal human thymus extracts: activation of potential drugs for AIDS therapy. Biochem Biophys Res Commun 148:1252-8
Verhoef, V; Ashmun, R; Fridland, A (1986) Rhodamine 123 and flow cytometry to monitor the cytotoxic actions of nucleoside analogues in nondividing human lymphocytes. Anticancer Res 6:1117-21
Fridland, A; Connelly, M C; Robbins, T J (1986) Tiazofurin metabolism in human lymphoblastoid cells: evidence for phosphorylation by adenosine kinase and 5'-nucleotidase. Cancer Res 46:532-7
Verhoef, V; Fridland, A (1985) Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts. Cancer Res 45:3646-50
Fridland, A; Verhoef, V (1985) Metabolism and selectivity of arabinonucleoside in human lymphoid cells. Proc Soc Exp Biol Med 179:456-62