Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA033022-03S1
Application #
3170948
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1982-07-01
Project End
1985-08-31
Budget Start
1984-07-01
Budget End
1985-08-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
Schools of Medicine
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
Chuang, L F; Zhao, F K; Chuang, R Y (1989) Isolation and purification of protein kinase C from human leukemia ML-1 cells phosphorylation of human leukemia RNA polymerase II in vitro. Biochim Biophys Acta 992:87-95
Zhao, F K; Chuang, L F; Israel, M et al. (1989) Adriamycin interacts with diacylglycerol to inhibit human leukemia protein kinase C. Anticancer Res 9:225-9
Zhao, F K; Chuang, L F; Israel, M et al. (1989) Cremophor EL, a widely used parenteral vehicle, is a potent inhibitor of protein kinase C. Biochem Biophys Res Commun 159:1359-67
Wang, L F; Doi, R H; Chuang, L F et al. (1989) Bluetongue virus-17 fusion protein ns1 expressed in Escherichia coli by pUC vectors. Biochem Biophys Res Commun 162:892-9
Lameh, J; Chuang, R Y; Israel, M et al. (1989) Nucleoside uptake and membrane fluidity studies on N-trifluoroacetyladriamycin-14-O-hemiadipate-treated human leukemia and lymphoma cells. Cancer Res 49:2905-8
Chuang, L F; Chuang, R Y (1988) The 24,000 Da subunit is not required for the RNA synthesis activity of chicken leukemia RNA polymerase II. Biochimie 70:1397-400
Lameh, J; Chuang, L F; Israel, M et al. (1988) Mechanistic studies on N-benzyladriamycin-14-valerate (AD 198), a highly lipophilic alkyl adriamycin analog. Anticancer Res 8:689-93
Wu, J C; Chernow, M; Boehme, R E et al. (1988) Kinetics and inhibition of reverse transcriptase from human and simian immunodeficiency viruses. Antimicrob Agents Chemother 32:1887-90
Chuang, L F; Chuang, R Y; Acton, E M et al. (1987) Effect of morpholinyladriamycin analogs and adriamycin on the activities of DNA polymerase alpha and RNA polymerase II of chicken leukemia cells. J Pharmacol Exp Ther 242:372-7
Chuang, L F; Cooper, R H; Yau, P et al. (1987) Protein kinase C phosphorylates leukemia RNA polymerase II. Biochem Biophys Res Commun 145:1376-83

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