Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA033225-09
Application #
3171186
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1990-09-15
Project End
1993-08-31
Budget Start
1990-09-15
Budget End
1991-08-31
Support Year
9
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Glaxosmithkline
Department
Type
DUNS #
City
King of Prussia
State
PA
Country
United States
Zip Code
19406
Pelus, L M (1989) Modulation of myelopoiesis by prostaglandin E2: demonstration of a novel mechanism of action in vivo. Immunol Res 8:176-84
Ottmann, O G; Abboud, M; Welte, K et al. (1989) Stimulation of human hematopoietic progenitor cell proliferation and differentiation by recombinant human interleukin 3. Comparison and interactions with recombinant human granulocyte-macrophage and granulocyte colony-stimulating factors. Exp Hematol 17:191-7
Nocka, K H; Ottman, O G; Pelus, L M (1989) The role of marrow accessory cell populations in the augmentation of human erythroid progenitor cell (BFU-E) proliferation by prostaglandin E. Leuk Res 13:527-34
Pelus, L M (1989) Blockade of prostaglandin biosynthesis in intact mice dramatically augments the expansion of committed myeloid progenitor cells (colony-forming units-granulocyte, macrophage) after acute administration of recombinant human IL-1 alpha. J Immunol 143:4171-9
Nocka, K H; Pelus, L M (1988) Cell cycle specific effects of deferoxamine on human and murine hematopoietic progenitor cells. Cancer Res 48:3571-5
Pelus, L M; Vadhan-Raj, S (1988) Modulation of responsiveness of chronic myelogenous leukemia granulocyte-macrophage colony-forming cells to growth regulation following in vivo treatment with recombinant gamma-interferon. Am J Hematol 28:21-6
Gentile, P S; Pelus, L M (1988) In vivo modulation of myelopoiesis by prostaglandin E2. IV. Prostaglandin E2 induction of myelopoietic inhibitory activity. J Immunol 141:2714-20
Pelus, L M; Ottmann, O G; Nocka, K H (1988) Synergistic inhibition of human marrow granulocyte-macrophage progenitor cells by prostaglandin E and recombinant interferon-alpha, -beta, and -gamma and an effect mediated by tumor necrosis factor. J Immunol 140:479-84
Pelus, L M; Levi, E; Welte, K (1988) The response of human marrow colony-forming units-granulocyte and macrophage to inhibition by prostaglandin E and acidic isoferritins is associated with expression of MHC class II antigens and requires the participation of a CD8+ T lymphokine. J Immunol 141:1658-64
Ottmann, O G; Pelus, L M (1988) Differential proliferative effects of transforming growth factor-beta on human hematopoietic progenitor cells. J Immunol 140:2661-5

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