Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA034082-09
Application #
2088628
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1987-02-01
Project End
1996-11-30
Budget Start
1993-12-01
Budget End
1996-11-30
Support Year
9
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Biochemistry
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Vaisman, A; Varchenko, M; Umar, A et al. (1998) The role of hMLH1, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: correlation with replicative bypass of platinum-DNA adducts. Cancer Res 58:3579-85
Vaisman, A; Varchenko, M; Said, I et al. (1997) Cell cycle changes associated with formation of Pt-DNA adducts in human ovarian carcinoma cells with different cisplatin sensitivity. Cytometry 27:54-64
Delmastro, D A; Li, J; Vaisman, A et al. (1997) DNA damage inducible-gene expression following platinum treatment in human ovarian carcinoma cell lines. Cancer Chemother Pharmacol 39:245-53
Chaney, S G; Sancar, A (1996) DNA repair: enzymatic mechanisms and relevance to drug response. J Natl Cancer Inst 88:1346-60
Vaisman, A; Keeney, S; Nichols, A F et al. (1996) Cisplatin-induced alterations in the expression of the mRNAs for UV-damage recognition protein. Oncol Res 8:7-12
Petersen, L N; Mamenta, E L; Stevnsner, T et al. (1996) Increased gene specific repair of cisplatin induced interstrand crosslinks in cisplatin resistant cell lines, and studies on carrier ligand specificity. Carcinogenesis 17:2597-602
Vaisman, A; Chaney, S G (1995) Induction of UV-damage recognition protein by cisplatin treatment. Biochemistry 34:105-14
Mamenta, E L; Poma, E E; Kaufmann, W K et al. (1994) Enhanced replicative bypass of platinum-DNA adducts in cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res 54:3500-5
Schmidt, W; Chaney, S G (1993) Role of carrier ligand in platinum resistance of human carcinoma cell lines. Cancer Res 53:799-805
Nichols, A F; Schmidt, W J; Chaney, S G et al. (1992) Limitations of the in vitro repair synthesis assay for probing the role of DNA repair in platinum resistance. Chem Biol Interact 81:223-31

Showing the most recent 10 out of 24 publications