Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA034798-04A1
Application #
3172621
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1983-05-01
Project End
1987-06-30
Budget Start
1986-12-01
Budget End
1987-06-30
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Boston University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Taub, M E; Shen, W C (1992) Polarity in the transcytotic processing of apical and basal membrane-bound peroxidase-polylysine conjugates in MDCK cells. J Cell Physiol 150:283-90
Wan, J; Taub, M E; Shah, D et al. (1992) Brefeldin A enhances receptor-mediated transcytosis of transferrin in filter-grown Madin-Darby canine kidney cells. J Biol Chem 267:13446-50
Mandel, R; Ryser, H J; Niaki, B et al. (1991) Isolation of variants of Chinese hamster ovary cells with abnormally low levels of GSH: decreased ability to cleave endocytosed disulfide bonds. J Cell Physiol 149:60-5
Wan, J S; Persiani, S; Shen, W C (1990) Transcellular processing of disulfide- and thioether-linked peroxidase--polylysine conjugates in cultured MDCK epithelial cells. J Cell Physiol 145:9-15
Feener, E P; Shen, W C; Ryser, H J (1990) Cleavage of disulfide bonds in endocytosed macromolecules. A processing not associated with lysosomes or endosomes. J Biol Chem 265:18780-5
Shen, W C (1990) Acid-sensitive dissociation between poly(lysine) and histamine-modified poly(glutamate) as a model for drug-releasing from carriers in endosomes. Biochim Biophys Acta 1034:122-4
Shen, W C; Wan, J S; Shen, D (1990) Proteolytic processing in a non-lysosomal compartment is required for transcytosis of protein-polylysine conjugates in cultured Madin-Darby canine kidney cells. Biochem Biophys Res Commun 166:316-23
Persiani, S; Ballou, B; Shen, W C et al. (1989) In vivo antitumor effect of methotrexate conjugated to a monoclonal IgM antibody specific for stage-specific embryonic antigen-1, on MH-15 mouse teratocarcinoma. Cancer Immunol Immunother 29:167-70
Persiani, S; Shen, W C (1989) Increase of poly(L-lysine) uptake but not fluid phase endocytosis in neuraminidase pretreated Madin-Darby canine kidney (MDCK) cells. Life Sci 45:2605-10
Ryser, H J; Li, W; Mandel, R et al. (1988) Stable variant of LM fibroblast defective in fluid-phase but competent in receptor-mediated endocytosis. J Cell Physiol 137:490-6

Showing the most recent 10 out of 14 publications