We have recently demonstrated that a system based on the control of radiant heat exchange can provide an effective and safe means of delivering 41-42C whole body hyperthermia (WBH) in mice, pigs and humans. The general goals of this project are A) to refine a unique radiant heat system capable of providing systemic hyperthermia as a routine procedure, and B) to undertake studies of WBH alone or in combination with radiation for the treatment of neoplastic diseases. From these studies we will establish the cost, efficacy and safety of our WBH system. Using these data the feasibility of performing later multi-institutional trials of WBH in combination with other treatment modalities will be delineated.
The specific aims of this project include: 1. Completion of a toxicity study of WBH which incorporates a traditional Phase I dose escalation schema. 2. Initiation and completion of a Phase I/II study of WBH with whole body irradiation for the treatment of chronic lymphocytic leukemia or favorable lymphoma. 3. Initiation and completion of a Phase I/II study of WBH with local irradiation for the treatment of advanced non-small cell lung carcinoma confined to the thorax.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA035361-03
Application #
3172934
Study Section
Radiation Study Section (RAD)
Project Start
1983-08-01
Project End
1988-01-31
Budget Start
1986-02-01
Budget End
1988-01-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Robins, H; Hugander, A; Besozzi, M et al. (1991) Beta-blockade during whole-body hyperthermia: a toxicity study in the dog. Int J Hyperthermia 7:263-70
Robins, H I; Hugander, A; Cohen, J D (1989) Whole body hyperthermia in the treatment of neoplastic disease. Radiol Clin North Am 27:603-10
Cohen, J D; Robins, H I; Mulcahy, R T et al. (1988) Interactions between hyperthermia and irradiation in two human lymphoblastic leukemia cell lines in vitro. Cancer Res 48:3576-80
Cohen, J D; Robins, H I (1987) Hyperthermic enhancement of cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) cytotoxicity in human leukemia cells in vitro. Cancer Res 47:4335-7
Robins, H I; Kalin, N H; Shelton, S E et al. (1987) Neuroendocrine changes in patients undergoing whole body hyperthermia. Int J Hyperthermia 3:99-105
Robins, H I; Kalin, N H; Shelton, S E et al. (1987) Rise in plasma beta-endorphin, ACTH, and cortisol in cancer patients undergoing whole body hyperthermia. Horm Metab Res 19:441-3
Hugander, A; Robins, H I; Martin, P et al. (1987) Temperature distribution during radiant heat whole-body hyperthermia: experimental studies in the dog. Int J Hyperthermia 3:199-208
Martin, P A; Robins, H I; Dennis, W H (1987) Monitoring body site temperatures during systemic hyperthermia. Crit Care Med 15:163-4
Robins, H I; Dennis, W H; Neville, A J et al. (1985) A nontoxic system for 41.8 degrees C whole-body hyperthermia: results of a Phase I study using a radiant heat device. Cancer Res 45:3937-44