The principal objectives of the proposed research are to determine the ultrasonic propagation properties in intact tissue and to correlate these parameters to those obtained with the ultrasonic computer-assisted tomographic technique. Specifically, ultrasonic properties of attenuation, velocity, and absorption will be compared to the tissue constituents water, total protein, collagen, and fat with the view of determining the influence of such constituents upon ultrasonic propagation properties. Four measurement techniques will be employed to determine the spatial distribution of ultrasonic attenuation, velocity, and absorption. They include a radiation force balance technique, the transient thermoelectric technique, the scanning laser acoustic microscope technique, and ultrasonic computer-assisted tomographic technique. Collaboration between the Ultrasonics Research Laboratory at Mayo Clinic and the Bioacoustics Research Laboratory at the University of Illinois will continue to 1) develop methods for calibrating basic measurements at both laboratories, 2) result in evaluation at both labs of human tissue taken from the same organ, and of calibration phantoms.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA036029-09
Application #
3173536
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1983-06-01
Project End
1989-09-30
Budget Start
1988-04-01
Budget End
1989-09-30
Support Year
9
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Type
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
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O'Brien Jr, W D; Erdman Jr, J W; Hebner, T B (1988) Ultrasonic propagation properties (@ 100 MHz) in excessively fatty rat liver. J Acoust Soc Am 83:1159-66
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Tervola, K M; Gummer, M A; Erdman Jr, J W et al. (1985) Ultrasonic attenuation and velocity properties in rat liver as a function of fat concentration: a study at 100 MHz using a scanning laser acoustic microscope. J Acoust Soc Am 77:307-13