Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA036097-03S1
Application #
3173587
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1984-03-01
Project End
1987-03-31
Budget Start
1986-03-01
Budget End
1987-03-31
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Flowers-Geary, L; Bleczinki, W; Harvey, R G et al. (1996) Cytotoxicity and mutagenicity of polycyclic aromatic hydrocarbon ortho-quinones produced by dihydrodiol dehydrogenase. Chem Biol Interact 99:55-72
Flowers-Geary, L; Harvey, R G; Penning, T M (1995) Identification of benzo[a]pyrene-7,8-dione as an authentic metabolite of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in isolated rat hepatocytes. Carcinogenesis 16:2707-15
Flowers-Geary, L; Harvey, R G; Penning, T M (1993) Cytotoxicity of polycyclic aromatic hydrocarbon o-quinones in rat and human hepatoma cells. Chem Res Toxicol 6:252-60
Jarabak, J; Harvey, R G (1993) Studies on three reductases which have polycyclic aromatic hydrocarbon quinones as substrates. Arch Biochem Biophys 303:394-401
Shou, M; Harvey, R G; Penning, T M (1993) Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts. Carcinogenesis 14:475-82
Nair, R V; Nettikumara, A N; Cortez, C et al. (1992) Comparative metabolism of dibenz[a,j]anthracene and 7-methyldibenz[a,j]anthracene in primary cultures of mouse keratinocytes. Chem Res Toxicol 5:532-40
Flowers-Geary, L; Harvey, R G; Penning, T M (1992) Examination of diols and diol epoxides of polycyclic aromatic hydrocarbons as substrates for rat liver dihydrodiol dehydrogenase. Chem Res Toxicol 5:576-83
Shou, M; Harvey, R G; Penning, T M (1992) Contribution of dihydrodiol dehydrogenase to the metabolism of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in fortified rat liver subcellular fractions. Carcinogenesis 13:1575-82
Nair, R V; Gill, R D; Nettikumara, A N et al. (1991) Characterization of covalently modified deoxyribonucleosides formed from dibenz[a,j]anthracene in primary cultures of mouse keratinocytes. Chem Res Toxicol 4:115-22
Bigger, C A; Flickinger, D J; Strandberg, J et al. (1990) Mutational specificity of the anti 1,2-dihydrodiol 3,4-epoxide of 5-methylchrysene. Carcinogenesis 11:2263-5

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