The total synthesis of the antitumor drug ravidomycin is proposed. The naphthalene aglycone of this C-glycoside is also found in toromycin and gilvogarcin V. The plan is to append the deoxyaminoaltrose sugar onto a properly functionalized benzoquinone. The synthetic methodology which is envisioned for the connection of ring D is a Meerwein arylation or a palladium mediated arylation of benzoquinone.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA036868-02
Application #
3174458
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1985-05-01
Project End
1988-04-30
Budget Start
1986-05-01
Budget End
1987-04-30
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Alabama in Tuscaloosa
Department
Type
Schools of Arts and Sciences
DUNS #
City
Tuscaloosa
State
AL
Country
United States
Zip Code
35487