Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA036902-07
Application #
3174536
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1984-12-01
Project End
1991-08-31
Budget Start
1990-12-01
Budget End
1991-08-31
Support Year
7
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Carnegie-Mellon University
Department
Type
Schools of Engineering
DUNS #
052184116
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Yuan, F; Leunig, M; Berk, D A et al. (1993) Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. Microvasc Res 45:269-89
Boucher, Y; Jain, R K (1992) Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. Cancer Res 52:5110-4
Leunig, M; Yuan, F; Menger, M D et al. (1992) Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res 52:6553-60
Kaufman, E N; Jain, R K (1992) In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching. J Immunol Methods 155:1-17
Baxter, L T; Yuan, F; Jain, R K (1992) Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data. Cancer Res 52:5838-44
Kaufman, E N; Jain, R K (1992) Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays. Cancer Res 52:4157-67
Kaufman, E N; Jain, R K (1991) Measurement of mass transport and reaction parameters in bulk solution using photobleaching. Reaction limited binding regime. Biophys J 60:596-610
Yuan, F; Baxter, L T; Jain, R K (1991) Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies. Cancer Res 51:3119-30
Baxter, L T; Jain, R K (1991) Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution. Microvasc Res 41:252-72
Clauss, M A; Jain, R K (1990) Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues. Cancer Res 50:3487-92

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