Several laboratories have demonstrated the potential of immunotoxins (anti-tumor monoclonal antibody-toxin conjugates) for anti-tumor therapy. A major problem with this technique, in addition to that of obtaining an appropriate monoclonal antibody, is the relatively short circulating half-life of immunotoxin and the potential of immunotoxin to induce an immunological response. The objective of this investigation is to evaluate the potential of using chemical modification with the water soluble polymer polyethylene glycol to increase circulating half-life and decrease immunogenicity of immunotoxin while maintaining both antibody and toxin activity. Similar studies have proven successful with several enzymes. (HI)

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037063-03
Application #
3174737
Study Section
Experimental Immunology Study Section (EI)
Project Start
1984-12-01
Project End
1988-11-30
Budget Start
1986-12-01
Budget End
1988-11-30
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of New Mexico
Department
Type
Schools of Medicine
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
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Anderson, W L; Tomasi, T B (1988) Polymer modification of antibody to eliminate immune complex and Fc binding. J Immunol Methods 109:37-42
Roberts, J C; Figard, S D; Mercer-Smith, J A et al. (1987) Preparation and characterization of copper-67 porphyrin-antibody conjugates. J Immunol Methods 105:153-64