The PI proposes to continue his studies on the molecular pathogenesis of AIDS-associated lymphomas. The PI has recently discovered that approximately 40% of the diffuse large cell lymphomas (DLCL) associated with AIDS contain rearrangements in the 5'noncoding region of the BCL-6 gene. In this project, he will further characterize the structural alterations of BCL-6 in DLCL, elucidate the biological consequences of BCL-6 alterations on tumor pathogenesis and Epstein-Barr virus gene expression, and attempt to identify additional genetic alterations associated with lymphomas in AIDS.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037295-18
Application #
6362531
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Read-Connole, Elizabeth Lee
Project Start
1984-04-01
Project End
2002-07-16
Budget Start
2001-03-26
Budget End
2002-07-16
Support Year
18
Fiscal Year
2001
Total Cost
$356,721
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
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