DNA ploidy patterns in cell nuclei from cytologic and histologic samples will be used to provide tumor diagnostic and prognostic information. Our rapid, computer-controlled, video-based microphotometer system allows the recording of DNA-ploidy patterns within minutes, with statistically valid sample sizes, thus making this valuable method practical as a routine clinical laboratory test. It is intended to standardize the methodology for this purpose, to assemble and examine a clinical database to correlate ploidy patterns with clinical implications, to establish objective measures for ploidy pattern evaluation, and to establish the sensitivity for the detection of aneuploidy. An inexpensive, microprocessor-based microscope attachment and graphic display has been designed as a prototype for a practical pathology laboratory instrument. (3)
| Hamilton, P W; Montironi, R; Abmayr, W et al. (1995) Clinical applications of Bayesian belief networks in pathology. Pathologica 87:237-45 |
| Xiao, J; Christen, R; Minimo, C et al. (1994) An algorithm for automatic tracking of nuclear boundaries. Anal Quant Cytol Histol 16:240-6 |
| Bibbo, M; Xiao, J; Christen, R et al. (1994) Use of computer graphic filters for the nuclear grading of hematoxylin and eosin-stained specimens from prostatic lesions. Anal Quant Cytol Histol 16:183-8 |
| Minimo, C; Galera-Davidson, H; Xiao, J et al. (1994) Importance of different nuclear morphologic patterns in grading prostatic adenocarcinoma. An expanded model for computer graphic filters. Anal Quant Cytol Histol 16:307-14 |
| Bibbo, M; Bartels, P H; Pfeifer, T et al. (1993) Belief network for grading prostate lesions. Anal Quant Cytol Histol 15:124-35 |
| Christen, R; Xiao, J; Minimo, C et al. (1993) Chromatin texture features in hematoxylin and eosin-stained prostate tissue. Anal Quant Cytol Histol 15:383-8 |
| Bartels, P H; Thompson, D; Bibbo, M et al. (1992) Bayesian belief networks in quantitative histopathology. Anal Quant Cytol Histol 14:459-73 |
| Schark, C; Fulton, N; Yashiro, T et al. (1992) The value of measurement of ras oncogenes and nuclear DNA analysis in the diagnosis of Hurthle cell tumors of the thyroid. World J Surg 16:745-51;discussion 752 |
| Minimo, C; Bartels, P H; Kim, D H et al. (1991) Value of the cribriformity factor in grading prostatic carcinoma. Anal Quant Cytol Histol 13:411-7 |
| Bibbo, M; Kim, D H; Pfeifer, T et al. (1991) Histometric features for the grading of prostatic carcinoma. Anal Quant Cytol Histol 13:61-8 |
Showing the most recent 10 out of 37 publications
