Various aspects of the actions of human interferon (IFN)-gamma will be examined with the aid of biological and biochemical techniques. Both highly purified natural and recombinant, E. coli-derived IFN-gamma will be employed in these studies. Studies will include evaluations of the relative efficiency of IFN-gamma in inhibiting various viral functions in different cell systems and in some immunoregulatory activities. We shall also continue to explore regulatory interactions between IFN-gamma and some other lymphokines and monokines. Monoclonal antibodies specific for IFN-gamma will be prepared and characterized with respect to their ability to bind to and neutralize natural and recombinant IFN-gamma. (HF)

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037385-03
Application #
3175247
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1984-02-01
Project End
1988-01-31
Budget Start
1986-02-01
Budget End
1987-01-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012