This is a proposal for the continuation of work in the development and clinical application of parallel processed high speed ultrasound phased array imaging systems. Over the past period extensive studies aimed at improving Exploso system performance have resulted in improved instrumentation. Based on the results it is proposed to extend the Explososcan approach to producing real time 3-D ultrasound images. New 2-D arrays and receive processing architectures are proposed which would permit 64 to 1 parallelism in the receive mode. Images will be displayed on standard 2-D displays and provisions made to permit the simultaneous display of several tomographic planes. Hardware and software will be developed to permit the display of projection images with perspective and real time C-mode images. Incorporation of custom VLSI circuits are contemplated to reduce system complexity and enhance performance. Explososcan methods will be incorporated in two real time flow imaging systems. The first is a high speed color Doppler unit now under construction which will have a frame rate 4 times higher than conventional units. The second uses speckle motion tracking rather than Doppler techniques and consequently is independent of errors introduced by the Doppler angle. The incorporation of flow imaging with multiplanar images to produce 3-D flow images is an additional goal. Another goal is t study motion of the left ventricle with high speed imaging to assess the possibility of detecting mechanical correlates of abnormal ventricular depolarization. All 3-D images and color Doppler results will be compared with standard clinical images and other Doppler results.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037586-09
Application #
3175374
Study Section
(SSS)
Project Start
1981-07-01
Project End
1990-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
9
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Duke University
Department
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Phillips, P J; Kadi, A P; Von Ramm, O T (1995) Feasibility study for a two-dimensional diagnostic ultrasound velocity mapping system. Ultrasound Med Biol 21:217-29
Bashford, G R; von Ramm, O T (1995) Speckle structure in three dimensions. J Acoust Soc Am 98:35-42
Davidsen, R E; Jensen, J A; Smith, S W (1994) Two-dimensional random arrays for real time volumetric imaging. Ultrason Imaging 16:143-63
Bohs, L N; Friemel, B H; McDermott, B A et al. (1993) A real time system for quantifying and displaying two-dimensional velocities using ultrasound. Ultrasound Med Biol 19:751-61
Phillips, P J; von Ramm, O T; Swartz, J C et al. (1993) Optical transducer for reception of ultrasonic waves. J Acoust Soc Am 93:1182-91
Bohs, L N; Friemel, B H; McDermott, B A et al. (1993) Real-time system for angle-independent US of blood flow in two dimensions: initial results. Radiology 186:259-61
Smith, S W; Trahey, G E; von Ramm, O T (1992) Two-dimensional arrays for medical ultrasound. Ultrason Imaging 14:213-33
Bohs, L N; Zhao, D; Trahey, G E (1992) Phase aberration correction using echo signals from moving targets. II: Experimental system and results. Ultrason Imaging 14:111-20
Sheikh, K H; Davidson, C J; Newman, G E et al. (1991) Intravascular ultrasound assessment of the renal artery. Ann Intern Med 115:22-5
Fortin, D F; Sheikh, K H; Kisslo, J (1991) The utility of echocardiography in the diagnostic strategy of postinfarction ventricular septal rupture: a comparison of two-dimensional echocardiography versus Doppler color flow imaging. Am Heart J 121:25-32

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