Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA037789-04
Application #
3175616
Study Section
Project Start
1987-01-01
Project End
1988-06-30
Budget Start
1987-01-01
Budget End
1988-06-30
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Holt, P R; Luk, G D (1990) Aging and intestinal polyamine metabolism in the rat. Exp Gerontol 25:173-81
Luk, G D; Zhang, S Z; Hamilton, S R (1989) Effects of timing of administration and dose of difluoromethylornithine on rat colonic carcinogenesis. J Natl Cancer Inst 81:421-7
Zhang, S Z; Luk, G D; Hamilton, S R (1988) Alpha-difluoromethylornithine-induced inhibition of growth of autochthonous experimental colonic tumors produced by azoxymethane in male F344 rats. Cancer Res 48:6498-503
Luk, G D; Yang, P (1988) Distribution of polyamines and their biosynthetic enzymes in intestinal adaptation. Am J Physiol 254:G194-200
Kanof, M E; Rance, N E; Hamilton, S R et al. (1987) Congenital diarrhea with intestinal inflammation and epithelial immaturity. J Pediatr Gastroenterol Nutr 6:141-6
Luk, G D; Casero Jr, R A (1987) Polyamines in normal and cancer cells. Adv Enzyme Regul 26:91-105
Luk, G D; Yang, P (1987) Polyamines in intestinal and pancreatic adaptation. Gut 28 Suppl:95-101
Luk, G D; Hamilton, S R; Yang, P et al. (1986) Kinetic changes in mucosal ornithine decarboxylase activity during azoxymethane-induced colonic carcinogenesis in the rat. Cancer Res 46:4449-52
Luk, G D; Baylin, S B (1986) Anchorage dependency effects on difluoromethylornithine cytotoxicity in human lung carcinoma cells. Cancer Res 46:1844-8
Luk, G D; Abeloff, M D; McCann, P P et al. (1986) Long-term maintenance therapy of established human small cell variant lung carcinoma implants in athymic mice with a cyclic regimen of difluoromethylornithine. Cancer Res 46:1849-53

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