Thy-1 is a cell surface differentiation marker expressed predominantly in the brain of many mammalian species including man. In some species, notably rats and mice. Thy-1 is also expressed on lymphoid tissue. Its preferential expression on synapses and its appearance during morphologic development of the brain suggest that it may play a role in synapse formation. The tissue-specific expression of Thy-1 and its variation in patterns of expression among different species make Thy-1 an ideal model for studying the fundamental mechanisms that underlie gene regulation. We propose to identify DNA sequences that regulate the Thy-1 gene in a tissue-specific manner. Recombinant DNA constructs will be used in transient and stable transformation systems. In addition, transgenic mice expressing the human Thy-1 gene will be used to study the mechanisms responsible for the differing patterns of Thy-1 expression in different species.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA038404-05
Application #
3176531
Study Section
Neurology C Study Section (NEUC)
Project Start
1984-01-01
Project End
1991-08-31
Budget Start
1989-09-06
Budget End
1991-08-31
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost
Name
North Shore University Hospital
Department
Type
DUNS #
City
Manhasset
State
NY
Country
United States
Zip Code
11030
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Seki, T; Moriuchi, T; Chang, H C et al. (1985) Structural organization of the rat thy-1 gene. Nature 313:485-7