Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA038621-06
Application #
3176713
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1985-01-01
Project End
1993-07-31
Budget Start
1989-12-15
Budget End
1990-07-31
Support Year
6
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Poteat, H T; Sklar, J (1997) A simplified polymerase chain reaction assay for detection of chromosomal translocations in hematologic malignancies. Diagn Mol Pathol 6:3-9
Kuo, F C; Sklar, J (1997) Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers. J Exp Med 186:1547-56
Davi, F; Gocke, C; Smith, S et al. (1996) Lymphocytic progenitor cell origin and clonal evolution of human B-lineage acute lymphoblastic leukemia. Blood 88:609-21
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Pear, W S; Aster, J C; Scott, M L et al. (1996) Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 183:2283-91
Tycko, B; Ritz, J; Sallan, S et al. (1992) Changing antigen receptor gene rearrangements in a case of early pre-B cell leukemia: evidence for a tumor progenitor cell with stem cell features and implications for monitoring residual disease. Blood 79:481-8
Aster, J C; Kobayashi, Y; Shiota, M et al. (1992) Detection of the t(14;18) at similar frequencies in hyperplastic lymphoid tissues from American and Japanese patients. Am J Pathol 141:291-9
Kobayashi, Y; Tycko, B; Soreng, A L et al. (1991) Transrearrangements between antigen receptor genes in normal human lymphoid tissues and in ataxia telangiectasia. J Immunol 147:3201-9
Ellisen, L W; Bird, J; West, D C et al. (1991) TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66:649-61
Tycko, B; Smith, S D; Sklar, J (1991) Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia. J Exp Med 174:867-73

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