Abstract

The goals of this grant are to continue the characterization of a novel monocyte activating factor (MAF) produced by the T-cell hybridoma FtF3 (ATCC HB 9713) developed in this laboratory.
The specific aims are: 1. Sequence both MAF proteins 2. Prepare synthetic peptides to confirm sequence/activity relationship, function, and for production of monoclonal antibodies. 3. Production of monoclonal antibodies. 4. Make cDNA and/or oligonucleotide probes, and isolated the gene. Identification of these factors are important in the understanding of the immunology of lymphocyte/monocyte interactions, and may be of potential clinical value in augmenting the immune response against tumors and microorganisms.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA039441-04A4
Application #
3178422
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1985-05-01
Project End
1993-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225