The purpose of this research is to develop and evaluate the use of surgically implanted, thermally regulating ferromagnetic implants for inducing hyperthermia in tumors. The research can be grouped into two broad categories: 1. The clinical evaluation of the existing seeds in a number of clinical sites. This clinical work focusses on Phase I type trials where efficacy of heating is the primary endpoint and the development of clinical techniques, procedures and possibly instrumentation is the principal research process. We propose to take advantage of the clinical facilities of the University of Arizona, the University of California at San Francisco, and the City of Hope Medical Center. 2. The further development of the method by introducing better ferromagnetic materials and seed configurations and by introducing a permanently implanted version of the seeds. Both of these categories of research are bolstered by the development of better instrumentation and methods of characterizing the implants and by the development of quality assurance tests and procedures. It is anticipated that randomized clinical trials will be developed and introduced subsequently in later years of the grant, but the detailed specification of these are premature until experience is obtained in Phase I.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA039468-04
Application #
3178477
Study Section
Radiation Study Section (RAD)
Project Start
1985-07-01
Project End
1991-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Arizona
Department
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85722
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