Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA039691-08
Application #
2089912
Study Section
Virology Study Section (VR)
Project Start
1985-12-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Pharmacology
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Zhu, J; Aurelian, L (1997) AP-1 cis-response elements are involved in basal expression and Vmw110 transactivation of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10). Virology 231:301-12
Nelson, J W; Zhu, J; Smith, C C et al. (1996) ATP and SH3 binding sites in the protein kinase of the large subunit of herpes simplex virus type 2 of ribonucleotide reductase (ICP10). J Biol Chem 271:17021-7
Smith, C C; Luo, J H; Aurelian, L (1996) The protein kinase activity of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) fused to the extracellular domain of the epidermal growth factor receptor is ligand-inducible. Virology 217:425-34
Hunter, J C; Smith, C C; Bose, D et al. (1995) Intracellular internalization and signaling pathways triggered by the large subunit of HSV-2 ribonucleotide reductase (ICP10). Virology 210:345-60
Smith, C C; Luo, J H; Hunter, J C et al. (1994) The transmembrane domain of the large subunit of HSV-2 ribonucleotide reductase (ICP10) is required for protein kinase activity and transformation-related signaling pathways that result in ras activation. Virology 200:598-612
Wymer, J P; Aprhys, C M; Chung, T D et al. (1992) Immediate early and functional AP-1 cis-response elements are involved in the transcriptional regulation of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10). Virus Res 23:253-70
Luo, J H; Aurelian, L (1992) The transmembrane helical segment but not the invariant lysine is required for the kinase activity of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10). J Biol Chem 267:9645-53
Smith, C C; Kulka, M; Wymer, J P et al. (1992) Expression of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is required for virus growth and neoplastic transformation. J Gen Virol 73 ( Pt 6):1417-28
Chung, T D; Luo, J H; Wymer, J P et al. (1991) Leucine repeats in the large subunit of herpes simplex virus type 2 ribonucleotide reductase (RR;ICP10) are involved in RR activity and subunit complex formation. J Gen Virol 72 ( Pt 5):1139-44
Smith, C C; Wymer, J P; Luo, J et al. (1991) Genomic sequences homologous to the protein kinase region of the bifunctional herpes simplex virus type 2 protein ICP10. Virus Genes 5:215-26

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