The overall aim of the proposed research is to understand how lymphoid cell-mediated immunity destroys cells bearing alien surface antigens. The immediate aim is to determine how alloimmune cytolytic T lymphocytes interact and adhere to histoincompatible target cells. (LB)
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| Cosgrove, J M; Howcroft, T K; Tatum, S M et al. (1991) Membranolytic and nucleolytic activities of cytolytic T lymphocyte clones. Biochem Biophys Res Commun 179:1562-7 |
| Howcroft, T K; Lindquist, R R (1991) The protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) inhibits PMA-induced promiscuous cytolytic activity but not specific cytolytic activity by a cloned cytolytic T lymphocyte. Biochem Biophys Res Commun 179:720-5 |
| Howcroft, T K; Tatum, S M; Cosgrove, J M et al. (1988) Protein kinase C (PKC) inhibitors inhibit primary (1-0) but not secondary (1-1) or cloned cytotoxic T lymphocytes. Biochem Biophys Res Commun 154:1280-6 |
