Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA040251-11
Application #
2090172
Study Section
Special Emphasis Panel (ZRG3-RAD (01))
Project Start
1985-08-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Waterloo
Department
Type
DUNS #
City
Waterloo
State
ON
Country
Canada
Zip Code
N2 3-G1
Senisterra, G A; Lepock, J R (2000) Thermal destabilization of transmembrane proteins by local anaesthetics. Int J Hyperthermia 16:17-Jan
Booth, V K; Roberts, J C; Warters, R L et al. (2000) Radioprotective thiolamines WR-1065 and WR-33278 selectively denature nonhistone nuclear proteins. Radiat Res 153:813-22
Freeman, M L; Borrelli, M J; Meredith, M J et al. (1999) On the path to the heat shock response: destabilization and formation of partially folded protein intermediates, a consequence of protein thiol modification. Free Radic Biol Med 26:737-45
Borrelli, M J; Stafford, D M; Rausch, C M et al. (1998) Diamide-induced cytotoxicity and thermotolerance in CHO cells. J Cell Physiol 177:483-92
Freeman, M L; Huntley, S A; Meredith, M J et al. (1997) Destabilization and denaturation of cellular protein by glutathione depletion. Cell Stress Chaperones 2:191-8
McDuffee, A T; Senisterra, G; Huntley, S et al. (1997) Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response. J Cell Physiol 171:143-51
Ali, A; Fernando, P; Smith, W L et al. (1997) Preferential activation of HSF-binding activity and hsp70 gene expression in Xenopus heart after mild hyperthermia. Cell Stress Chaperones 2:229-37
Senisterra, G A; Huntley, S A; Escaravage, M et al. (1997) Destabilization of the Ca2+-ATPase of sarcoplasmic reticulum by thiol-specific, heat shock inducers results in thermal denaturation at 37 degrees C. Biochemistry 36:11002-11
Borrelli, M J; Lepock, J R; Frey, H E et al. (1996) Excess protein in nuclei isolated from heat-shocked cells results from a reduced extractability of nuclear proteins. J Cell Physiol 167:369-79
Borrelli, M J; Stafford, D M; Karczewski, L A et al. (1996) Thermotolerance expression in mitotic CHO cells without increased translation of heat shock proteins. J Cell Physiol 169:420-8

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