Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA040407-01S1
Application #
3180285
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1985-09-01
Project End
1988-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Friedman, B; Fujiki, H; Rosner, M R (1990) Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor. Cancer Res 50:533-8
Hicks, K; Friedman, B; Rosner, M R (1989) Basic fibroblast-like growth factor is present in the conditioned medium of simian sarcoma virus transformed NRK cells. Biochem Biophys Res Commun 164:1323-30
Hicks, K; Friedman, B; Rosner, M R (1989) Basic and acidic fibroblast growth factors modulate the epidermal growth factor receptor by a protein kinase C-independent pathway. Biochem Biophys Res Commun 164:796-803
Wattenberg, E V; McNeil, P L; Fujiki, H et al. (1989) Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway. J Biol Chem 264:213-9
Friedman, B A; van Amsterdam, J; Fujiki, H et al. (1989) Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters. Proc Natl Acad Sci U S A 86:812-6
Takishima, K; Friedman, B; Fujiki, H et al. (1988) Thapsigargin, a novel promoter, phosphorylates the epidermal growth factor receptor at threonine 669. Biochem Biophys Res Commun 157:740-6
McCaffrey, P; Ran, W; Campisi, J et al. (1987) Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells. J Biol Chem 262:1442-5
Friedman, B A; Rosner, M R (1987) Growth factors modify the epidermal growth factor receptor through multiple pathways. J Cell Biochem 34:1-11
McCaffrey, P G; Rosner, M R (1987) Growth state-dependent regulation of protein kinase C in normal and transformed murine cells. Cancer Res 47:1081-6
McCaffrey, P G; Rosner, M R; Kikkawa, U et al. (1987) Characterization of protein kinase C from normal and transformed cultured murine fibroblasts. Biochem Biophys Res Commun 146:140-6

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