Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA041521-10
Application #
2090479
Study Section
Pathology B Study Section (PTHB)
Project Start
1986-01-07
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
10
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Northwest Hospital and Medical Center
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98133
Schwientek, T; Almeida, R; Levery, S B et al. (1998) Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis. J Biol Chem 273:29331-40
Amado, M; Almeida, R; Carneiro, F et al. (1998) A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family. J Biol Chem 273:12770-8
Holmes, E H; Xu, Z; Sherwood, A L et al. (1995) Structure-function analysis of human alpha 1-->3fucosyltransferases. A GDP-fucose-protected, N-ethylmaleimide-sensitive site in FucT-III and FucT-V corresponds to Ser178 in FucT-IV. J Biol Chem 270:8145-51
Hu, J; Stults, C L; Holmes, E H et al. (1994) Structural characterization of intermediates in the biosynthetic pathway of neolacto glycosphingolipids: differential expression in human leukaemia cells. Glycobiology 4:251-7
Meldgaard, P; Holmes, E H; Bennett, E P et al. (1994) Blood group ABO-related glycosylation of urothelial cell lines: immunocytological, enzymatic, and genetic characterization. Cancer Res 54:2440-7
Holmes, E H; Macher, B A (1993) Specificity of fucose transfer to GlcNAc residues of extended chain neolacto-series glycolipids catalyzed by human alpha 1-->3fucosyltransferases: effect of the lipidic environment on the myeloid enzyme form. Arch Biochem Biophys 301:190-9
Holmes, E H (1993) Human Lewis alpha 1-->3/4fucosyltransferase: specificity of fucose transfer to GlcNAc beta 1-->3Gal beta 1-->4Glc beta 1-->1Cer (LcOse3Cer). Glycobiology 3:77-81
Holmes, E H; Greene, T G (1993) De novo synthesis of type 1 lacto-series glycolipids in human colonic adenocarcinoma cells: efficient synthesis of the Le(a) antigen and absence of brefeldin A-induced inhibition of its synthesis in Colo 205 cells. Arch Biochem Biophys 305:328-40
Symington, F W; Holmes, E H; Symington, B E (1992) Human epidermal keratinocyte expression of sialyl-Lewis X. J Invest Dermatol 99:601-7
Sherwood, A L; Greene, T G; Holmes, E H (1992) Stable expression of a cDNA encoding a human beta 1 --> 3galactosyltransferase responsible for lacto-series type 1 core chain synthesis in non-expressing cells: variation in the nature of cell surface antigens expressed. J Cell Biochem 50:165-77

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