Abstract

The participation of human papillomaviruses in the development of cervical cancer is supported by the demonstration in the tumor cells of papillomavirus group-specific antigen and viral particles. In this project we will attempt to induce neoplastic progression of papillomavirus-infected lesions of human cervix by treating the grafts with agents which may represent additional risk factors for the development of cervical cancer. Some of these agents include benzopyrene, n-methylnitrosamine, estrogens, and herpes simplex virus type 2.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA042011-05
Application #
3182739
Study Section
Special Emphasis Panel (SSS (G))
Project Start
1986-04-01
Project End
1991-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Ghim, S; Christensen, N D; Kreider, J W et al. (1991) Comparison of neutralization of BPV-1 infection of C127 cells and bovine fetal skin xenografts. Int J Cancer 49:285-9
Kreider, J W; Patrick, S D; Cladel, N M et al. (1990) Experimental infection with human papillomavirus type 1 of human hand and foot skin. Virology 177:415-7
Kreider, J W; Howett, M K; Leure-Dupree, A E et al. (1987) Laboratory production in vivo of infectious human papillomavirus type 11. J Virol 61:590-3