There are approximately 6,000 children diagnosed annually with cancer in the United States. Leukemia represents approximately 32% of all malignancies in persons less than 15 years of age. When examining children less than 1 year of age, leukemia has the second highest incidence rate and the highest mortality rate of all childhood malignancies. The annual incidence of leukemia during the first year of life is approximately 32 per million live births. We propose to investigate the role of family history and selected in utero and postnatal exposures in the etiology of acute lymphoblastic leukemia (ALL) and non-lymphoblastic leukemia (ANLL) in children 18 months of age and under. Of primary interest will be exposures resulting from medical care as well as those resulting from parental occupations and living environment. Specific exposures to be investigated included ionizing radiation, medications pesticidies, chemical solvents and petroleum products. Quantitation of risk associated with exposures and family history will be made separately for ALL and ANLL by contrasting cases to a set of age- and race-matched regional population controls (two per case). Specific medical exposures will be validated for all cases and control. In addition, assessment will be made of association between exposure and biologically defined subgroups based on malignant cell chromosomal abnormalities and cell phenotype through comparison of exposed and non-exposed cases. Analyses will be performed comparing cases of ALL to ANLL to assess possible differences in reported exposures. Lastly, reported exposures will be assessed for possible association with survival of cases.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA042479-03
Application #
3183886
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1987-01-15
Project End
1990-06-30
Budget Start
1989-01-01
Budget End
1989-12-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
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Ross, Julie A; Xie, Yang; Davies, Stella M et al. (2003) Prescription medication use during pregnancy and risk of infant leukemia (United States). Cancer Causes Control 14:447-51
Swensen, A R; Ross, J A; Shu, X O et al. (2001) Pet ownership and childhood acute leukemia (USA and Canada). Cancer Causes Control 12:301-3
Ross, J A (2000) Dietary flavonoids and the MLL gene: A pathway to infant leukemia? Proc Natl Acad Sci U S A 97:4411-3
Wen, W Q; Shu, X O; Steinbuch, M et al. (2000) Paternal military service and risk for childhood leukemia in offspring. Am J Epidemiol 151:231-40
Wen, W Q; Shu, X O; Sellers, T et al. (1998) Family history of cancer and autoimmune disease and risk of leukemia in infancy: a report from the Children's Cancer Group (United States and Canada). Cancer Causes Control 9:161-71
Olson, J E; Shu, X O; Ross, J A et al. (1997) Medical record validation of maternally reported birth characteristics and pregnancy-related events: a report from the Children's Cancer Group. Am J Epidemiol 145:58-67
Mertens, A C; Robison, L L (1997) Evaluation of parental participation in a case-control study of infant leukaemia. Paediatr Perinat Epidemiol 11:240-6
Ross, J A; Potter, J D; Shu, X O et al. (1997) Evaluating the relationships among maternal reproductive history, birth characteristics, and infant leukemia: a report from the Children's Cancer Group. Ann Epidemiol 7:172-9
Ross, J A; Potter, J D; Reaman, G H et al. (1996) Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group. Cancer Causes Control 7:581-90

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