We will utilize a number of different viral and non-viral systems to elucidate the mechanism(s) by which proto-oncogenes become activated, and to ascertain their role in the malignant cell. Systems to be studied will include: (a) ALV-induced lymphomas; (b) RPV-induced fibrosarcomas; (c) rapidly-appearing angiosarcomas and lymphomas induced by RPV, or by RPV/ALV recombinants; (d) Burkitt lymphoma; (e) human chronic myelogenous leukemia. Efforts will be made to determine the role of the myc gene product in normal and transformed cells, and to identify sequences and second-site genes responsible for control of its expression. We will also attempt to identify """"""""new"""""""" oncogenes involved in RPV-induced fibrosarcomas, and in various stages of tumor progression in chronic myelogenous leukemia.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA043250-05
Application #
3185385
Study Section
Experimental Virology Study Section (EVR)
Project Start
1986-09-01
Project End
1992-08-31
Budget Start
1990-09-01
Budget End
1992-08-31
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065