Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA043280-04
Application #
3185438
Study Section
Project Start
1987-01-01
Project End
1991-06-30
Budget Start
1988-07-01
Budget End
1991-06-30
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Gesell, M S; Luk, G D (1993) A defined collagen substrate and nutrient diffusion gradient culture system allows human colon cancer cells to assume a more differentiated phenotype. Epithelial Cell Biol 2:45-54
Elitsur, Y; Majumdar, A P; Sakr, W A et al. (1991) Epidermal growth factor regulation of DNA synthesis in human colonic lamina propria lymphocytes. Dig Dis Sci 36:335-40
Elitsur, Y; Freedland, C P; Luk, G D (1990) Inhibition of DNA synthesis in human peripheral and lamina propria lymphocytes by 5-aminosalicylic acid and hydrocortisone. Reg Immunol 3:56-61
Conteas, C N; Mutchnick, M G; Palmer, K C et al. (1990) Cellular levels of thymosin immunoreactive peptides are linked to proliferative events: evidence for a nuclear site of action. Proc Natl Acad Sci U S A 87:3269-73
Elitsur, Y; Mutchnick, M G; Sakr, W A et al. (1990) Thymosin alpha 1 and thymosin beta 4 modulate human colonic lamina propria lymphocyte function. Immunopharmacology 20:89-96
Moshier, J A; Gilbert, J D; Skunca, M et al. (1990) Isolation and expression of a human ornithine decarboxylase gene. J Biol Chem 265:4884-92
Elitsur, Y; Bull, A W; Luk, G D (1990) Modulation of human colonic lamina propria lymphocyte proliferation. Effect of bile acids and oxidized fatty acids. Dig Dis Sci 35:212-20
Neelam, S S; Bernabei, A; Freedland, C et al. (1990) Combination of flavone acetic acid (FAA) with adriamycin, cis-platinum and difluoromethylornithine (DFMO) in vitro against human colon cancer cells. Invest New Drugs 8:263-8
Luk, G D; Canellakis, Z N (1990) Diacetylputrescine and its analog suppress c-myc expression and activation of human B-lymphocytes. Biochem Int 20:169-76
Celano, P; Berchtold, C M; Giardiello, F M et al. (1989) Modulation of growth gene expression by selective alteration of polyamines in human colon carcinoma cells. Biochem Biophys Res Commun 165:384-90

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