Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA043839-09
Application #
2091280
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1986-03-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Louisville
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Louisville
State
KY
Country
United States
Zip Code
40292
Singleton, D W; Lei, X D; Webb, S J et al. (1999) Cytochrome P-450 mRNAs are modulated by dehydroepiandrosterone, nafenopin, and triiodothyronine. Drug Metab Dispos 27:193-200
Lubet, R A; Gordon, G B; Prough, R A et al. (1998) Modulation of methylnitrosourea-induced breast cancer in Sprague Dawley rats by dehydroepiandrosterone: dose-dependent inhibition, effects of limited exposure, effects on peroxisomal enzymes, and lack of effects on levels of Ha-Ras mutations. Cancer Res 58:921-6
Song, W; Chen, J; Dean, W L et al. (1998) Purification and characterization of hamster liver microsomal 7alpha-hydroxycholesterol dehydrogenase. Similarity to type I 11beta-hydroxysteroid dehydrogenase. J Biol Chem 273:16223-8
Song, W; Pierce Jr, W M; Saeki, Y et al. (1996) Endogenous 7-oxocholesterol is an enzymatic product: characterization of 7 alpha-hydroxycholesterol dehydrogenase activity of hamster liver microsomes. Arch Biochem Biophys 328:272-82
Webb, S J; Xiao, G H; Geoghegan, T E et al. (1996) Regulation of CYP4A expression in rat by dehydroepiandrosterone and thyroid hormone. Mol Pharmacol 49:276-87
Prough, R A; Webb, S J; Wu, H Q et al. (1994) Induction of microsomal and peroxisomal enzymes by dehydroepiandrosterone and its reduced metabolite in rats. Cancer Res 54:2878-86
Gettings, S D; Brewer, C B; Pierce Jr, W M et al. (1990) Enhanced decomposition of oxyferrous cytochrome P450CIA1 (P450cam) by the chemopreventive agent 3-t-butyl-4-hydroxyanisole. Arch Biochem Biophys 276:500-9
Tweedie, D J; Prough, R A; Burke, M D (1988) Effects of induction on the metabolism and cytochrome P-450 binding of harman and other beta-carbolines. Xenobiotica 18:785-96
Tweedie, D J; Burke, M D (1987) Metabolism of the beta-carbolines, harmine and harmol, by liver microsomes from phenobarbitone- or 3-methylcholanthrene-treated mice. Identification and quantitation of two novel harmine metabolites. Drug Metab Dispos 15:74-81