Quinocarcin Mechanism of Action - Drugs for Breast Cancer

Williams, Robert Michael

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA043969-08
• Application #: 2091337
• Study Section: Bio-Organic and Natural Products Chemistry Study Section (BNP)
• Project Start: 1987-01-01
• Project End: 1998-02-28
• Budget Start: 1996-03-01
• Budget End: 1997-02-28
• Support Year: 8
• Fiscal Year: 1996

Institution

• Name: Colorado State University-Fort Collins
• Department: Chemistry
• Type: Schools of Arts and Sciences
• DUNS #: 112617480
• City: Fort Collins
• State: CO
• Country: United States
• Zip Code: 80523

Publications

Herberich, B; Scott, J D; Williams, R M (2000) Synthesis of a netropsin conjugate of a water-soluble epi-quinocarcin analogue: the importance of stereochemistry at nitrogen. Bioorg Med Chem 8:523-32

Hefner, J; Rubenstein, S M; Ketchum, R E et al. (1996) Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis. Chem Biol 3:479-89

Flanagan, M E; Rollins, S B; Williams, R M (1995) Netropsin and spermine conjugates of a water-soluble quinocarcin analog: analysis of sequence-specific DNA interactions. Chem Biol 2:147-56

Williams, R M; Flanagan, M E; Tippie, T N (1994) O2-dependent cleavage of DNA by tetrazomine. Biochemistry 33:4086-92