Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA044387-10
Application #
2091472
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1987-07-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1998-04-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Thompson, T A; Kim, K; Gould, M N (1998) Harvey ras results in a higher frequency of mammary carcinomas than Kirsten ras after direct retroviral transfer into the rat mammary gland. Cancer Res 58:5097-104
Gould, M N (1995) Rodent models for the study of etiology, prevention and treatment of breast cancer. Semin Cancer Biol 6:147-52
Ariazi, E A; Thompson, T A; Burkholder, J K et al. (1995) Transcriptional regulatory and response mapping of the rat Ha-ras upstream sequence using primary mammary epithelial cells. Carcinogenesis 16:965-8
Kamiya, K; Yasukawa-Barnes, J; Mitchen, J M et al. (1995) Evidence that carcinogenesis involves an imbalance between epigenetic high-frequency initiation and suppression of promotion. Proc Natl Acad Sci U S A 92:1332-6
Thompson, T A; Gould, M N; Burkholder, J K et al. (1993) Transient promoter activity in primary rat mammary epithelial cells evaluated using particle bombardment gene transfer. In Vitro Cell Dev Biol 29A:165-70
Gould, M N (1993) Cellular and molecular aspects of the multistage progression of mammary carcinogenesis in humans and rats. Semin Cancer Biol 4:161-9
Oakley, C S; Welsch, M A; Zhai, Y F et al. (1993) Comparative abilities of athymic nude mice and severe combined immune deficient (SCID) mice to accept transplants of induced rat mammary carcinomas: enhanced transplantation efficiency of those rat mammary carcinomas that have elevated expression of neu o Int J Cancer 53:1002-7
Wang, B; Kennan, W S; Yasukawa-Barnes, J et al. (1992) Difference in the response of neu and ras oncogene-induced rat mammary carcinomas to early and late ovariectomy. Cancer Res 52:4102-5
Wang, B; Kennan, W S; Yasukawa-Barnes, J et al. (1991) Frequent induction of mammary carcinomas following neu oncogene transfer into in situ mammary epithelial cells of susceptible and resistant rat strains. Cancer Res 51:5649-54
Gould, M N; Clifton, K H; Kamiya, K et al. (1991) Quantitative and molecular comparison of initiation frequency of mammary carcinogenesis by radiation and chemical carcinogens. Radiat Environ Biophys 30:221-3

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