Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA044794-01
Application #
3187583
Study Section
Experimental Immunology Study Section (EI)
Project Start
1987-05-01
Project End
1992-04-30
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Morganelli, P M; Kitzmiller, T J; Hemmer, R et al. (1992) Redirected targeting of LDL to human monocyte Fc gamma receptors with bispecific antibodies. Arterioscler Thromb 12:1131-8
Shen, L (1992) A monoclonal antibody specific for immunoglobulin A receptor triggers polymorphonuclear neutrophil superoxide release. J Leukoc Biol 51:373-8
Erbe, D V; Pfefferkorn, E R; Fanger, M W (1991) Functions of the various IgG Fc receptors in mediating killing of Toxoplasma gondii. J Immunol 146:3145-51
Connor, R I; Dinces, N B; Howell, A L et al. (1991) Fc receptors for IgG (Fc gamma Rs) on human monocytes and macrophages are not infectivity receptors for human immunodeficiency virus type 1 (HIV-1): studies using bispecific antibodies to target HIV-1 to various myeloid cell surface molecules, including t Proc Natl Acad Sci U S A 88:9593-7
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Pfefferkorn, L C; Guyre, P M; Fanger, M W (1990) Functional comparison of the inductions of NADPH oxidase activity and Fc gamma RI in IFN gamma-treated U937 cells. Mol Immunol 27:263-72
Pfefferkorn, L C; Fanger, M W (1989) Cross-linking of the high affinity Fc receptor for human immunoglobulin G1 triggers transient activation of NADPH oxidase activity. Continuous oxidase activation requires continuous de novo receptor cross-linking. J Biol Chem 264:14112-20
Shen, L; Graziano, R F; Fanger, M W (1989) The functional properties of Fc gamma RI, II and III on myeloid cells: a comparative study of killing of erythrocytes and tumor cells mediated through the different Fc receptors. Mol Immunol 26:959-69
Shen, L; Lasser, R; Fanger, M W (1989) My 43, a monoclonal antibody that reacts with human myeloid cells inhibits monocyte IgA binding and triggers function. J Immunol 143:4117-22

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