Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA045814-08
Application #
2092035
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1987-07-01
Project End
1996-12-31
Budget Start
1995-01-01
Budget End
1996-12-31
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Bhatia, R; Munthe, H A; Verfaillie, C M (1999) Role of abnormal integrin-cytoskeletal interactions in impaired beta1 integrin function in chronic myelogenous leukemia hematopoietic progenitors. Exp Hematol 27:1384-96
Bhatia, R; Munthe, H A; Verfaillie, C M (1998) Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors. Leukemia 12:1708-17
Bhatia, R; Verfaillie, C M (1998) Inhibition of BCR-ABL expression with antisense oligodeoxynucleotides restores beta1 integrin-mediated adhesion and proliferation inhibition in chronic myelogenous leukemia hematopoietic progenitors. Blood 91:3414-22
Verfaillie, C M; Hurley, R; Lundell, B I et al. (1997) Integrin-mediated regulation of hematopoiesis: do BCR/ABL-induced defects in integrin function underlie the abnormal circulation and proliferation of CML progenitors? Acta Haematol 97:40-52
Bhatia, R; McGlave, P B; Miller, J S et al. (1997) A clinically suitable ex vivo expansion culture system for LTC-IC and CFC using stroma-conditioned medium. Exp Hematol 25:980-91
Hurley, R W; McCarthy, J B; Wayner, E A et al. (1997) Monoclonal antibody crosslinking of the alpha 4 or beta 1 integrin inhibits committed clonogenic hematopoietic progenitor proliferation. Exp Hematol 25:321-8
Lundell, B I; McCarthy, J B; Kovach, N L et al. (1997) Activation of beta1 integrins on CML progenitors reveals cooperation between beta1 integrins and CD44 in the regulation of adhesion and proliferation. Leukemia 11:822-9
Verfaillie, C M; Catanzaro, P (1996) Direct contact with stroma inhibits proliferation of human long-term culture initiating cells. Leukemia 10:498-504
Lundell, B I; McCarthy, J B; Kovach, N L et al. (1996) Activation-dependent alpha5beta1 integrin-mediated adhesion to fibronectin decreases proliferation of chronic myelogenous leukemia progenitors and K562 cells. Blood 87:2450-8
Gupta, P; McCarthy, J B; Verfaillie, C M (1996) Stromal fibroblast heparan sulfate is required for cytokine-mediated ex vivo maintenance of human long-term culture-initiating cells. Blood 87:3229-36

Showing the most recent 10 out of 48 publications