Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA045823-07
Application #
2092040
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1987-09-30
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1997-03-31
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Pharmacology
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Flesher, J W; Horn, J; Lehner, A F (1998) Carcinogenicity of 1-hydroxy-3-methylcholanthrene and its electrophilic sulfate ester 1-sulfooxy-3-methylcholanthrene in Sprague-Dawley rats. Biochem Biophys Res Commun 243:30-5
Flesher, J W; Horn, J; Lehner, A F (1997) 7-Sulfooxymethyl-12-methylbenz[a]anthracene is an exceptionally reactive electrophilic mutagen and ultimate carcinogen. Biochem Biophys Res Commun 231:144-8
Flesher, J W; Horn, J; Lehner, A F (1997) 6-sulfooxymethylbenzo[a]pyrene is an ultimate electrophilic and carcinogenic form of the intermediary metabolite 6-hydroxymethylbenzo[a]pyrene. Biochem Biophys Res Commun 234:554-8
Flesher, J W; Horn, J; Lehner, A F (1997) 7-Sulfooxymethylbenz[a]anthracene is an ultimate electrophilic and carcinogenic form of 7-hydroxymethylbenz[a]anthracene. Biochem Biophys Res Commun 231:712-6
Horn, J; Flesher, J W; Lehner, A F (1996) 1-Sulfooxymethylpyrene is an electrophilic mutagen and ultimate carcinogen of 1-methyl- and 1-hydroxymethylpyrene. Biochem Biophys Res Commun 228:105-9
Stansbury, K H; Flesher, J W; Gupta, R C (1994) Mechanism of aralkyl-DNA adduct formation from benzo[a]pyrene in vivo. Chem Res Toxicol 7:254-9
Flesher, J W; Myers, S R (1991) Rules of molecular geometry for predicting carcinogenic activity of unsubstituted polynuclear aromatic hydrocarbons. Teratog Carcinog Mutagen 11:41-54
Myers, S R; Flesher, J W (1991) Bioalkylation of benz[a]anthracene, 7-methylbenz[a]anthracene, and 12-methylbenz[a]anthracene in rat lung cytosol preparations. Biochem Pharmacol 41:1683-9
Myers, S R; Flesher, J W (1991) Metabolism of chrysene, 5-methylchrysene, 6-methylchrysene and 5,6-dimethylchrysene in rat liver cytosol, in vitro, and in rat subcutaneous tissue, in vivo. Chem Biol Interact 77:203-21
Flesher, J W; Myers, S R (1991) Methyl-substitution of benzene and toluene in preparations of human bone marrow. Life Sci 48:843-50

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