Abstract

This is a new application that concerns the development and optimization of a new generation of photosensitizers for photodynamic therapy (PDT) of tumors and other health conditions. The molecules selected for study are, chemically, of the naphthalocyanine (NC) family. NC's are based on a tetrapyrroloid macrocycle. Preliminary photophysicial studies have shown one representative of this class as having light absorption and photochemical characteristics that are required for improving upon the performance of the photosensitizer (hematoporphyrin derivative) currently undergoing chemical trials. The program involves a synthetic facet in which NC's of different structure, optical absorption and solubility properties will be synthesized and characterized (Dr. M. E. Kenny will collaborate here). There is a facet that requires the use of time- resolved kinetic methods to quantify the photophysical properties of the designated systems in a variety of environments. The third facet involveds photobiological studies at the cellular and animal tumor level (these last in collaboration with Dr. G. Jori). The three laboratories where this research will proceed are all excellently equipped with the requisite facilities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA046281-02
Application #
3189512
Study Section
Radiation Study Section (RAD)
Project Start
1988-09-01
Project End
1991-07-31
Budget Start
1989-08-01
Budget End
1990-07-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Bowling Green State University
Department
Type
Schools of Arts and Sciences
DUNS #
617407325
City
Bowling Green
State
OH
Country
United States
Zip Code
43403

  Publications

Aoudia, M; Guliaev, A B; Leontis, N B et al. (2000) Self-assembled complexes of oligopeptides and metalloporphyrins: measurements of the reorganization and electronic interaction energies for photoinduced electron-transfer reactions. Biophys Chem 83:121-40
Zuk, M M; Rihter, B D; Kenney, M E et al. (1994) Pharmacokinetic and tissue distribution studies of the photosensitizer bis(di-isobutyl octadecylsiloxy)silicon 2,3-naphthalocyanine (isoBOSINC) in normal and tumor-bearing rats. Photochem Photobiol 59:66-72
Biolo, R; Jori, G; Soncin, M et al. (1994) Photodynamic therapy of B16 pigmented melanoma with liposome-delivered Si(IV)-naphthalocyanine. Photochem Photobiol 59:362-5
Rodgers, M A (1993) Reflections on type I photodynamic damage. J Photochem Photobiol B 18:296-8
Oleinick, N L; Antunez, A R; Clay, M E et al. (1993) New phthalocyanine photosensitizers for photodynamic therapy. Photochem Photobiol 57:242-7
Bellemo, C; Jori, G; Rihter, B D et al. (1992) Si(IV)-naphthalocyanine: modulation of its pharmacokinetic properties through the use of hydrophilic axial ligands. Cancer Lett 65:145-50
Rihter, B D; Bohorquez, M D; Rodgers, M A et al. (1992) Two new sterically hindered phthalocyanines: synthetic and photodynamic aspects. Photochem Photobiol 55:677-80
Zuk, M M; Rihter, B D; Kenney, M E et al. (1991) Photosensitizers for tumor therapy: determination of bis(di-isobutyl octadecylsiloxy)silicon 2,3-naphthalocyanine (isoBOSINC) in rat tissue and serum by high-performance liquid chromatography. J Chromatogr 568:437-44
Cuomo, V; Jori, G; Rihter, B et al. (1991) Tumour-localising and -photosensitizing properties of liposome-delivered Ge(IV)-octabutoxy-phthalocyanine. Br J Cancer 64:93-5
Cuomo, V; Jori, G; Rihter, B et al. (1990) Liposome-delivered Si(IV)-naphthalocyanine as a photodynamic sensitiser for experimental tumours: pharmacokinetic and phototherapeutic studies. Br J Cancer 62:966-70

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