Abstract

The goal of this project is to identify the site of key genetic events in the development of Wilms' tumors. A genomic DNA library of region p13 on chromosome 11 will be utilized to establish the critical site(s) involved in formation of Wilms' tumor. Experiments are proposed to determine the location and identity of transcribed sequences in the Wilms' tumor gene region on 11p13.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA046720-02
Application #
3190083
Study Section
Pathology B Study Section (PTHB)
Project Start
1988-02-01
Project End
1993-01-31
Budget Start
1989-02-01
Budget End
1990-01-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
Hospitals
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Fraizer, G C; Wu, Y J; Hewitt, S M et al. (1994) Transcriptional regulation of the human Wilms' tumor gene (WT1). Cell type-specific enhancer and promiscuous promoter. J Biol Chem 269:8892-900
Miwa, H; Beran, M; Saunders, G F (1992) Expression of the Wilms' tumor gene (WT1) in human leukemias. Leukemia 6:405-9
Ton, C C; Hirvonen, H; Miwa, H et al. (1991) Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region. Cell 67:1059-74
Weil, M M; Huff, V; Compton, D A et al. (1990) An XmnI polymorphism detected by a human genomic clone from chromosomal band 11p13 [D11S416] Nucleic Acids Res 18:689
Compton, D A; Weil, M M; Bonetta, L et al. (1990) Definition of the limits of the Wilms tumor locus on human chromosome 11p13. Genomics 6:309-15
Ton, C C; Huff, V; Weil, M M et al. (1990) A BglII RFLP detected by the probe JA8-1 at human chromosome band 11p13 (D11S417). Nucleic Acids Res 18:1084
Huff, V; Compton, D A; Strong, L C et al. (1990) A panel of restriction fragment length polymorphisms for chromosomal band 11p13. Hum Genet 84:253-7
Huff, V; Meadows, A; Riccardi, V M et al. (1990) Parental origin of de novo constitutional deletions of chromosomal band 11p13. Am J Hum Genet 47:155-60
Compton, D A; Weil, M M; Jones, C et al. (1988) Long range physical map of the Wilms' tumor-aniridia region on human chromosome 11. Cell 55:827-36
Genuardi, M; Saunders, G F (1988) Localization of the HLA class II-associated invariant chain gene to human chromosome band 5q32. Immunogenetics 28:53-6