Baylor College of Medicine seeks to participate in a collaborative effort to investigate the capability of ultrasonography, along with biological markers, to detect prostate cancer, to determine location, volume, extent and invasiveness, to diagnose prostate cancer earlier than convention techniques (digital rectal examination), and to assess the impact of ultrasonography on morbidity, disease progression, and survival in a group of patients at high risk for having clinically important prostate cancer. To carry out these investigations we propose 3 protocols spanning the full spectrum of prostate cancer. I. Clinicopathologic correlations of preoperative ultrasonography with whole-mount, step-sectioned, mapped radical prostatectomy specimens. II. Diagnosis of stage A prostate cancer by transrectal ultrasonography prior to prostatectomy for benign disease (BPH). III. Transrectal ultrasonography in advanced prostate cancer. Using the protocols finally selected by the collaborating I, II, III institutions, we propose to investigate the efficacy of ultrasonography and of biological markers in the early diagnosis and assessment of extent of prostate cancer using techniques to assure accurate analysis of the data. Based on our past experience (5 years) and working closely with a radiologist, biostatistician, and data management group, we will develop uniform and standardized techniques for performance and interpretation of prostate sonography to assure reproducibility. And we will obtain consistent and complete data so that the imaging results can be analyzed for optimal clinical applicability.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA047197-01
Application #
3190708
Study Section
(SRC)
Project Start
1988-05-01
Project End
1991-04-30
Budget Start
1988-05-01
Budget End
1989-04-30
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Ohori, M; Egawa, S; Shinohara, K et al. (1994) Detection of microscopic extracapsular extension prior to radical prostatectomy for clinically localized prostate cancer. Br J Urol 74:72-9
Ohori, M; Wheeler, T M; Greene, D R et al. (1993) Comparison of the pathologic features and DNA ploidy value of prostate cancers detectable by sonography and by palpation. Prostate 23:271-81
Ohori, M; Shinohara, K; Wheeler, T M et al. (1993) Ultrasonic detection of non-palpable seminal vesicle invasion: a clinicopathological study. Br J Urol 72:799-808
Egawa, S; Wheeler, T M; Greene, D R et al. (1992) Unusual hyperechoic appearance of prostate cancer on transrectal ultrasonography. Br J Urol 69:169-74
Egawa, S; Carter, S S; Wheeler, T M et al. (1992) Sonographic monitoring of prostate cancer after definitive radiotherapy. Urology 40:230-6
Greene, D R; Taylor, S R; Wheeler, T M et al. (1991) DNA ploidy by image analysis of individual foci of prostate cancer: a preliminary report. Cancer Res 51:4084-9
Egawa, S; Greene, D R; Flanagan, W F et al. (1991) Transrectal ultrasonography in stage A prostate cancer: detection of residual tumor after transurethral resection of prostate. J Urol 146:366-71
Egawa, S; Wheeler, T M; Scardino, P T (1991) The sonographic appearance of irradiated prostate cancer. Br J Urol 68:172-7
Greene, D R; Egawa, S; Hellerstein, D K et al. (1990) Sonographic measurements of transition zone of prostate in men with and without benign prostatic hyperplasia. Urology 36:293-9
Shinohara, K; Scardino, P T; Carter, S S et al. (1989) Pathologic basis of the sonographic appearance of the normal and malignant prostate. Urol Clin North Am 16:675-91

Showing the most recent 10 out of 11 publications