Cloning of Transformation Effector and Suppressor Genes

Zarbl, Helmut

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA047571-08
• Application #: 2092643
• Study Section: Pathology B Study Section (PTHB)
• Project Start: 1988-05-01
• Project End: 1997-06-30
• Budget Start: 1996-01-01
• Budget End: 1997-06-30
• Support Year: 8
• Fiscal Year: 1996

Institution

• Name: Fred Hutchinson Cancer Research Center
• DUNS #: 075524595
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98109

Publications

Mikheev, Andrei M; Mikheeva, Svetlana A; Liu, Binrong et al. (2004) A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation. Carcinogenesis 25:47-59

Athanassiou, M; Hu, Y; Jing, L et al. (1999) Stabilization and reactivation of the p53 tumor suppressor protein in nontumorigenic revertants of HeLa cervical cancer cells. Cell Growth Differ 10:729-37

Boylan, M O; Athanassiou, M; Houle, B et al. (1996) Activation of tumor suppressor genes in nontumorigenic revertants of the HeLa cervical carcinoma cell line. Cell Growth Differ 7:725-35

Kho, C J; Wang, Y; Zarbl, H (1996) Effect of decreased fte-1 gene expression on protein synthesis, cell growth, and transformation. Cell Growth Differ 7:1157-66

Van Amsterdam, J R; Wang, Y; Sullivan, R C et al. (1994) Elevated expression of the junB proto-oncogene is essential for v-fos induced transformation of Rat-1 cells. Oncogene 9:2969-76

Kho, C J; Zarbl, H (1992) Fte-1, a v-fos transformation effector gene, encodes the mammalian homologue of a yeast gene involved in protein import into mitochondria. Proc Natl Acad Sci U S A 89:2200-4

Zarbl, H; Kho, C J; Boylan, M O et al. (1991) Functional in vitro assays for the isolation of cell transformation effector and suppressor genes. Environ Health Perspect 93:83-9