Immunocompetence of Thymus Cells

Claman, Henry N.

Abstract

This project continues to investigate the immune responses, particularly the thymus-dependent phenomenon of contact hypersensitivity. We will continue to investigate the mechanisms of the development of contact sensitization. We will follow up on our studies of the induction of specific immunologic tolerance and its mechanisms. These include suppressor cells and clone inhibition and the relation between them.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 9R01CA047657-23
• Application #: 3191420
• Study Section: Immunobiology Study Section (IMB)
• Project Start: 1978-01-01
• Project End: 1992-12-31
• Budget Start: 1988-03-01
• Budget End: 1988-12-31
• Support Year: 23
• Fiscal Year: 1988

Institution

• Name: University of Colorado Denver
• Type: Schools of Medicine
• DUNS #: 065391526
• City: Aurora
• State: CO
• Country: United States
• Zip Code: 80045

Publications

Schiltz, P M; Giorno, R C; Claman, H N (1994) Increased ICAM-1 expression in the early stages of murine chronic graft-versus-host disease. Clin Immunol Immunopathol 71:136-41

Schiltz, P M; Lieber, J; Giorno, R C et al. (1993) Mast cell immunohistochemistry: non-immunological immunostaining mediated by non-specific F(ab')2-mast cell secretory granule interaction. Histochem J 25:642-7

Howell, C D; Yoder, T D; Vierling, J M (1991) Suppressor function of hepatic mononuclear inflammatory cells during murine chronic graft-vs-host disease. I. Macrophage-enriched cells mediate suppression in the liver. Cell Immunol 132:256-68

Claman, H N (1989) On scleroderma. Mast cells, endothelial cells, and fibroblasts. JAMA 262:1206-9