Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA047669-02
Application #
3191443
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1987-09-29
Project End
1992-07-31
Budget Start
1988-08-01
Budget End
1989-07-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Genelabs Technologies, Inc.
Department
Type
DUNS #
City
Redwood City
State
CA
Country
United States
Zip Code
94063

  Publications

Wright, S C; Zheng, H; Zhong, J et al. (1993) Role of protein phosphorylation in TNF-induced apoptosis: phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF-resistant U937 variants. J Cell Biochem 53:222-33
Wright, S C; Zhong, J; Zheng, H et al. (1993) Nicotine inhibition of apoptosis suggests a role in tumor promotion. FASEB J 7:1045-51
Larrick, J W; Wright, S C (1992) Modulation of viral infections by cytokines. Mol Biother 4:87-94
Wright, S C; Kumar, P; Tam, A W et al. (1992) Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. J Cell Biochem 48:344-55
Wright, S C; Tam, A W; Kumar, P (1992) Selection of tumor cell variants for resistance to tumor necrosis factor also induces a form of pleiotropic drug resistance. Cancer Immunol Immunother 34:399-406
Levrat, C; Larrick, J W; Wright, S C (1991) Tumor necrosis factor induces activation of mitochondrial succinate dehydrogenase. Life Sci 49:1731-7
Larrick, J W; Wright, S C (1990) Cytotoxic mechanism of tumor necrosis factor-alpha. FASEB J 4:3215-23