Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA048080-05
Application #
2092902
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1990-08-06
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Loyola University Chicago
Department
Pathology
Type
Schools of Medicine
DUNS #
791277940
City
Maywood
State
IL
Country
United States
Zip Code
60153
Wiers, K M; Lathers, D M; Wright, M A et al. (2000) Vitamin D3 treatment to diminish the levels of immune suppressive CD34+ cells increases the effectiveness of adoptive immunotherapy. J Immunother 23:115-24
Pandit, R; Lathers, D M; Beal, N M et al. (2000) CD34+ immune suppressive cells in the peripheral blood of patients with head and neck cancer. Ann Otol Rhinol Laryngol 109:749-54
Lathers, D M; Lubbers, E; Wright, M A et al. (1999) Dendritic cell differentiation pathways of CD34+ cells from the peripheral blood of head and neck cancer patients. J Leukoc Biol 65:623-8
Gabel, S; Benefield, J; Meisinger, J et al. (1999) Protein phosphatases 1 and 2A maintain endothelial cells in a resting state, limiting the motility that is needed for the morphogenic process of angiogenesis. Otolaryngol Head Neck Surg 121:463-8
Young, M R; Lathers, D M (1999) Myeloid progenitor cells mediate immune suppression in patients with head and neck cancers. Int J Immunopharmacol 21:241-52
Lathers, D M; Lubbers, E; Beal, N M et al. (1999) Cultures derived from peripheral blood CD34+ progenitor cells of head and neck cancer patients and from cord blood are functionally different. Hum Immunol 60:1207-15
Wright, M A; Wiers, K; Vellody, K et al. (1998) Stimulation of immune suppressive CD34+ cells from normal bone marrow by Lewis lung carcinoma tumors. Cancer Immunol Immunother 46:253-60
Wiers, K; Wright, M A; Vellody, K et al. (1998) Failure of tumor-reactive lymph node cells to kill tumor in the presence of immune-suppressive CD34+ cells can be overcome with vitamin D3 treatment to diminish CD34+ cell levels. Clin Exp Metastasis 16:275-82
Jackson, J; Meisinger, J; Patel, S et al. (1997) Protein phosphatase-2A associates with the cytoskeleton to maintain cell spreading and reduced motility of nonmetastatic Lewis lung carcinoma cells: the loss of this regulatory control in metastatic cells. Invasion Metastasis 17:199-209
Young, M R; Lozano, Y (1997) Inhibition of tumor invasiveness by 1alpha,25-dihydroxyvitamin D3 coupled to a decline in protein kinase A activity and an increase in cytoskeletal organization. Clin Exp Metastasis 15:102-10

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