Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA049042-02
Application #
3192995
Study Section
Virology Study Section (VR)
Project Start
1988-12-15
Project End
1990-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Institute for Cancer Research
Department
Type
DUNS #
872612445
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Brin, E; Yi, J; Skalka, A M et al. (2000) Modeling the late steps in HIV-1 retroviral integrase-catalyzed DNA integration. J Biol Chem 275:39287-95
Hindmarsh, P; Ridky, T; Reeves, R et al. (1999) HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro. J Virol 73:2994-3003
Cochrane, A W; Jones, K S; Beidas, S et al. (1991) Identification and characterization of intragenic sequences which repress human immunodeficiency virus structural gene expression. J Virol 65:5305-13
Katzman, M; Mack, J P; Skalka, A M et al. (1991) A covalent complex between retroviral integrase and nicked substrate DNA. Proc Natl Acad Sci U S A 88:4695-9
Khan, E; Mack, J P; Katz, R A et al. (1991) Retroviral integrase domains: DNA binding and the recognition of LTR sequences. Nucleic Acids Res 19:851-60
Bizub, D; Weber, I T; Cameron, C E et al. (1991) A range of catalytic efficiencies with avian retroviral protease subunits genetically linked to form single polypeptide chains. J Biol Chem 266:4951-8
Katz, R A; Merkel, G; Kulkosky, J et al. (1990) The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro. Cell 63:87-95
Kulkosky, J; Skalka, A M (1990) HIV DNA integration: observations and interferences. J Acquir Immune Defic Syndr 3:839-51
Katzman, M; Katz, R A; Skalka, A M et al. (1989) The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J Virol 63:5319-27