Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA049870-02
Application #
3194190
Study Section
Experimental Immunology Study Section (EI)
Project Start
1989-05-01
Project End
1990-06-30
Budget Start
1990-05-01
Budget End
1990-06-30
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037
Chu, P; Wierda, W G; Kipps, T J (2000) CD40 activation does not protect chronic lymphocytic leukemia B cells from apoptosis induced by cytotoxic T lymphocytes. Blood 95:3853-8
Kohsaka, H; Carson, D A; Rassenti, L Z et al. (1996) The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation. J Clin Invest 98:2794-800
Ranheim, E A; Cantwell, M J; Kipps, T J (1995) Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells. Blood 85:3556-65
Rassenti, L Z; Kohsaka, H; Kipps, T J (1995) Analysis of immunoglobulin VH gene repertoire by an anchored PCR-ELISA. Ann N Y Acad Sci 764:463-73
Ranheim, E A; Kipps, T J (1995) Tumor necrosis factor-alpha facilitates induction of CD80 (B7-1) and CD54 on human B cells by activated T cells: complex regulation by IL-4, IL-10, and CD40L. Cell Immunol 161:226-35
Martin, T; Crouzier, R; Weber, J C et al. (1994) Structure-function studies on a polyreactive (natural) autoantibody. Polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain. J Immunol 152:5988-96
Ranheim, E A; Kipps, T J (1993) Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med 177:925-35
Kipps, T J (1993) Immunoglobulin genes in chronic lymphocytic leukemia. Blood Cells 19:615-25;discussion 631-2
Kobayashi, R; Rassenti, L Z; Meisenholder, G et al. (1993) Autoantigen inhibits apoptosis of a human B cell leukemia that produces pathogenic rheumatoid factor. J Immunol 151:7273-83
Kipps, T J; Carson, D A (1993) Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases. Blood 81:2475-87

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