Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050350-06
Application #
2093724
Study Section
Radiation Study Section (RAD)
Project Start
1989-08-01
Project End
1997-07-31
Budget Start
1994-08-01
Budget End
1997-07-31
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Brown University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Leith, J T; Michelson, S (1995) Levels of selected growth factors in viable and necrotic regions of xenografted HCT-8 human colon tumours. Cell Prolif 28:279-86
Leith, J T; Michelson, S (1995) Secretion rates and levels of vascular endothelial growth factor in clone A or HCT-8 human colon tumour cells as a function of oxygen concentration. Cell Prolif 28:415-30
Michelson, S; Leith, J T (1995) Interlocking triads of growth control in tumors. Bull Math Biol 57:345-66
McCarty 3rd, L P; Karr, S M; Harris, B Z et al. (1995) Comparison of basic fibroblast growth factor levels in clone A human colon cancer cells in vitro with levels in xenografted tumours. Br J Cancer 72:10-6
Leith, J T (1994) Enhancement of thermal sensitivity of xenografted human DLD-2 tumors by administration of basic fibroblast growth factor. Radiat Res 138:139-42
Michelson, S; Leith, J T (1994) Dormancy, regression, and recurrence: towards a unifying theory of tumor growth control. J Theor Biol 169:327-38
Leith, J T; Quaranto, L; Padfield, G et al. (1993) Radiobiological studies of PC-3 and DU-145 human prostate cancer cells: x-ray sensitivity in vitro and hypoxic fractions of xenografted tumors in vivo. Int J Radiat Oncol Biol Phys 25:283-7
Leith, J T; Michelson, S (1993) Effects of administration of basic fibroblast growth factor on hypoxic fractions in xenografted DLD-2 human tumours: time dependence. Br J Cancer 68:727-31
Leith, J T; Padfield, G; Michelson, S (1992) Effects of partial hepatectomy on the growth characteristics and hypoxic fractions of xenografted DLD-2 human colon cancers. Radiat Res 132:263-8
Leith, J T; Papa, G; Quaranto, L et al. (1992) Modification of the volumetric growth responses and steady-state hypoxic fractions of xenografted DLD-2 human colon carcinomas by administration of basic fibroblast growth factor or suramin. Br J Cancer 66:345-8

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