Several recent reports have emphasized the potential advantages of tissue and bone selective dual-energy images for improving lesion detection and characterization. Systems investigated have included those using scanned slit detector systems and those employing conventional large-area receptor geometry. Failure to correct for x-ray scatter and beam hardening in the latter systems leads to nonuniformity of material selection and in particular, poor visualization of the thoracic spine. In addition, image noise has been a problem. We proposed to investigate a dual-energy radiographic system involving the following key elements. 1. Gadolinium prefiltration to produce a spectrum with low and high energy peaks. 2. A detector consisting of four sequential BaFBr storage phosphor plates which detect images of steadily increasing energy from a single radiographic exposure. 3. Spatially variable energy dependent scatter corrections. 4. Spatially variable beam hardening corrections. 5. An adaptation of a new dual-energy noise reduction algorithm recently introduced by Kalender for dual-energy CT. The proposed research includes optimization of the data acquisition system and image processing software, and five clinical studies which include: 1) pulmonary nodule detection, 2) evaluation of intrathoracic airways, 3) evaluation of intrathoracic bone fractures, 4) evaluation of the genitourinary system, and 5) comparative evaluation of anatomical features.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA050382-01
Application #
3194818
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1989-08-01
Project End
1993-05-31
Budget Start
1989-08-01
Budget End
1990-05-31
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715